Brain Organoid Systems

3-D deep-access extracellular electrophysiology + optogenetics + imaging

Our neuroscientist-designed brain organoid electrophysiology systems are optimised for high-resolution electrophysiology in structurally-complex 3D brain organoids

Current 2D planar electrode arrays and 3D organoids are like square pegs and round holes...

The advent of brain organoids, colloquially known as 'mini-brains', as an experimental and potential clinical platform provides a physiologically relevant in vitro 3D brain model for studying disease-dysfunction-processes, drug screening, biomarker assessment and more. Their key advantage is that brain organoids self-organise into complex 3D neuro-architectural structures that preserve key cell-to-cell interactions found in the human brain. However, the current "go-to" state-of-the-art technologies for organoid electrophysiology consist of 2D planar multi-electrode arrays (MEAs) which are geometrically incongruous with 3D organoids; at best they allow for recording from the bottom surface of an organoid and commonly require physical-compression or slicing of the organoid which, of course, disrupts the complex internal structure of the tissue.

Using a 2D planar MEA to record from a 3D organoid is akin to stuffing a square-peg into a round on to learn how we put our 'mini-brains' to work on solving this problem...

Label-free electrophysiological monitoring in intact organoids at the single cell spiking level combined with optogenetics and imaging

Our bespoke organoid electrophysiology systems leverage our renowned minimally-invasive in vivo silicon neural probes, repurposed in to a complete solution for user-definable 3D deep-access electrophysiology in intact organoids. Designed and optimised for single-unit recording in cell layers, the small and spatially-selective, yet low-impedance electrodes on our probes offer an optimal geometry for tandem multiple entry points across the active outer layers of intact organoids, whilst both preserving tissue structure and enabling the experimenter to freely search the entire organoid for activity 'hot-spots'.

Neuroscientist-Led Webinars...

Dive in to our focussed webinar, with question and answer section, to gain a unique insight in to the emerging field of human brain organoids and learn how to optimise your own brain organoids for single unit recording with optogenetic identification.

Ground-Breaking Organoid Research Using Our Probes - hot-off-the-press!

Learn how Sergiu Pasca's team transplanted human organoids into the brains of newborn rats, showing that these implanted organoids respond to stimuli and could influence the animals’ behaviour - literally 'mind-blowing' stuff!

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Download our Catalog

Browse our complete range of tools; find your ideal probes and accessories

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Bespoke organoid systems designed, installed and supported by expert neuroscientists

Our organoid systems are designed, assembled and installed in your lab by our in-house experienced organoid-expert neuroscientists; the modular architecture allows for bespoke tailoring to incorporate multi-modal investigation tools including 64 - 512 channels of electrophysiology (even more channels available upon request), optogenetics, wide-field- and epifluorescence imaging as well as patch-clamp, allowing you to create your dream rig. We can also:

  • train you in organoid-preparation protocols designed to facilitate spontaneous spiking and field activity
  • visit your lab to install your new organoid dream rig
  • guide you in establishing a data-analysis pipeline