Silicon Neural Probes
Electrodes / Geometry / Connectors
Copyright Cambridge NeuroTech 2014
Advanced Electrophysiology Systems
We offer a variety of probe geometries designed to reach a
wide range of targets, starting at 16 channels up to 64
channels per probe. Edge and Parallel styles are available as
single shank (16 channels), twin-shank (32 channels) and
quad-shank (64 channels), whereas our newest 64 channel
probes, H2 2×32 and H3 1×64 are only available on as twin-
shank and single-shank, respectively.
Our multi-shank probes have inter-shank spacing at 250 μm –
the minimum safe-distance between shanks so as to avoid
recording the same neurons on more than one electrode array
yet offering coverage in the horizontal dimension to, for
example, span mutliple cortical columns. In contrast, our single
shank 64 channel probes offer unparalleld depth-coverage,
without sacrifcing recording resolution, enabling recording
within an entire cortical column, for example.
Our probes are available in three standard lengths capable of
reaching a wide range of brain targets from rodents to larger
animals. Our standard lengths are 6 mm, 8 mm and 9 mm.
* If you require longer probes, e.g. deep targets in large
animals, please contact us to discuss joining our beta-tester
World-leading silicon neural probe technology enabling high-yield
single unit recording with optogenetics and drug delivery
We’re focussed on providing cutting-edge, reliable silicon neural probes with short lead-times (no more waiting months for your
probes!) allowing you get high-quality data quickly and efficiently. Our silicon neural probes are the only probes around that are
purpose-engineered for single unit recording + optogenetics, with minimal photoelectric artefacts and enhanced signal to
noise ratio. But that’s not all... our innovative probe architecture enables guaranteed alignment between our silicon neural probes
and our chronic microdrives and co-alignment with fibre optic cannulas / drug cannulas and 3-D stacking of multiple probes too!
Acute Probe: 32 electrodes
Chronic Zif Probe: 64 electrodes
Chronic Omentics Probe: 32 electrodes
Acute Probes - anaesthetized and head-fixed
Convenient packaging on a printed circuit board which can be
easily mounted on a stereotaxic frame using our Acute Probe
Holder. Probes can be cleaned and reused many times
Omnetics Probes - chronic
Our Ometics probes are built around a highly flexible cable
allowing movement of the probe with our Nano-Drive or for
floating implants. Available with 16, 32 and 64 channel
connectors for direct compatibility with a wide range of
standard amplifier systems.
Zif Probes - chronic
Our Zif Probes enable direct coupling of multiple probes (16,
32 and 64 channels) together via an Omnetics interface board
or direct in to next-generation ‘smart’ headstges to provide
comprehensive 3-D / multi-loci recording capability. Nano-
Drive mountable or floating-style implants.
Discover what our systems can offer your experiments:
Acute and Chronic Connector Options
We only make 15 μm ultra-thin probes which
minimize tissue damage and enhance chronic
performance. Watch this brief video and see for
yourself just how flexible and robust our thin
Our probes offer outstanding signal to noise ratio
(see our Testimonials) and long-term in vivo
stability that other probes and electrodes struggle to
match - watch this short video of live data from rat
prefrontal cortex and judge for yourself
Signal : Noise ratio
Our typical electrode impedance is 25-40 kOhm (~2x-10x lower than our
competitors) which brings you enhanced signal-to-noise ratio, leading to higher
single unit yields. Unlike our competitors, our electrode materials are also inert
and long-term stable in vivo.
NEW! H3 and H2 high-resolution probes
Unparalleled depth-coverage AND single unit resolution all in one – these unique
probes allow unparalleled depth coverage without having to sacrifice resolution,
with with 64 electrodes spaced evenly every 20 μm (H3) or 25 μm (H2), enabling
previously intractable experiments such as:
(1) record units in ALL cortical layers at once, or
(2) span cortex and hippocampus simultaneously, and much more!
Small probe dimensions (significantly smaller than our competitors) aid in
ensuring excellence in long-term stable chronic recording too – size really matters
for keeping neurons alive in vivo and that’s something we excel at – see here.
Edge and Parallel designs – available as 16, 32 and 64 channel probes
Edge-sites are spaced on 40 μm centres along the edge of the probe; this design
has a long and bountiful heritage having been pioneered by Gyorgy Buszaki for
hippocampal recording – see hippocampus data and read the Nature
Parallel sites, spaced on 25 μm centres offer uniform spacing of electrodes
across the array, optimised for spike sorting of small-sized, tightly packed
neurons. Explore cortex and striatum data gathered with this probe design.