Silicon Neural Probes Electrodes / Geometry / Connectors
Copyright Cambridge NeuroTech 2014

Advanced Electrophysiology Systems

Shank number

We offer a variety of probe geometries designed to reach a wide range of targets, starting at 16 channels up to 64 channels per probe. Edge and Parallel styles are available as single shank (16 channels), twin-shank (32 channels) and quad-shank (64 channels), whereas our newest  64 channel probes, H2 2×32 and H3 1×64 are only available on as twin- shank and single-shank, respectively.

Shank spacing

Our multi-shank probes have inter-shank spacing at 250 μm the minimum safe-distance between shanks so as to avoid recording the same neurons on more than one electrode array yet offering coverage in the horizontal dimension to, for example, span mutliple cortical columns. In contrast, our single shank 64 channel probes offer unparalleld depth-coverage, without sacrifcing recording resolution, enabling recording within an entire cortical column, for example.

Shank length

Our probes are available in three standard lengths capable of reaching a wide range of brain targets from rodents to larger animals. Our standard lengths are 6 mm, 8 mm and 9 mm. * If you require longer probes, e.g. deep targets in large animals, please contact us to discuss joining our beta-tester programme.
World-leading silicon neural probe technology enabling high-yield single unit recording with optogenetics and drug delivery
We’re focussed on providing cutting-edge, reliable silicon neural probes with short lead-times (no more waiting months for your probes!) allowing you get high-quality data quickly and efficiently. Our silicon neural probes are the only probes around that are purpose-engineered for single unit recording + optogenetics, with minimal photoelectric artefacts and enhanced signal to noise ratio. But that’s not all... our innovative probe architecture enables guaranteed alignment between our silicon neural probes and our chronic microdrives and co-alignment with fibre optic cannulas / drug cannulas and 3-D stacking of multiple probes too!
Acute Probe: 32 electrodes
Chronic Zif Probe: 64 electrodes
Chronic Omentics Probe: 32 electrodes

Acute Probes - anaesthetized and head-fixed

Convenient packaging on a printed circuit board which can be easily mounted on a stereotaxic frame using our Acute Probe Holder. Probes can be cleaned and reused many times between experiments.

Omnetics Probes - chronic

Our Ometics probes are built around a highly flexible cable allowing movement of the probe with our Nano-Drive or for floating implants. Available with 16, 32 and 64 channel connectors for direct compatibility with a wide range of standard amplifier systems.

Zif Probes - chronic

Our Zif Probes enable direct coupling of multiple probes (16, 32 and 64 channels) together via an Omnetics interface board or direct in to next-generation ‘smart’ headstges to provide comprehensive 3-D / multi-loci recording capability. Nano- Drive mountable or floating-style implants.
In-vivo Performance
Discover what our systems can offer your experiments:

Electrode Geometry

Probe Geometry

Acute and Chronic Connector Options

We only make 15 μm ultra-thin probes which minimize tissue damage and enhance chronic performance.  Watch this brief video and see for yourself just how flexible and robust our thin probes are.
Our probes offer outstanding signal to noise ratio (see our Testimonials) and long-term in vivo stability that other probes and electrodes struggle to match - watch this short video of live data from rat prefrontal cortex and judge for yourself
Microdrives Robotic Surgery Multi-Function Probes: 3-D Record + Opto + Drugs Wireless Optogenetics & Electrophysiology

Signal : Noise ratio

Our typical electrode impedance is 25-40 kOhm (~2x-10x lower than our competitors) which brings you enhanced signal-to-noise ratio, leading to higher single unit yields. Unlike our competitors, our electrode materials are also inert and long-term stable in vivo.

NEW!             H3 and H2 high-resolution probes

   NEW!

Unparalleled depth-coverage AND single unit resolution all in one – these unique

probes allow unparalleled depth coverage without having to sacrifice resolution,

with with 64 electrodes spaced evenly every 20 μm (H3) or 25 μm (H2), enabling

previously intractable experiments such as:

(1) record units in ALL cortical layers at once, or (2) span cortex and hippocampus simultaneously, and much more! Small probe dimensions (significantly smaller than our competitors) aid in ensuring excellence in long-term stable chronic recording too – size really matters for keeping neurons alive in vivo and that’s something we excel at – see here.

Edge and Parallel designs – available as 16, 32 and 64 channel probes

Edge-sites are spaced on 40 μm centres along the edge of the probe; this design has a long and bountiful heritage having been pioneered by Gyorgy Buszaki for hippocampal recording – see hippocampus data and read the Nature Neuroscience paper. Parallel sites, spaced on 25 μm centres offer uniform spacing of electrodes across the array, optimised for spike sorting of small-sized, tightly packed neurons. Explore cortex and striatum data gathered with this probe design.