Our neuroscientist-designed range of silicon neural probes are optimized for large-scale single unit recording combined with optogenetics in freely-behaving, head-fixed and anaesthetised animals ranging from mice to monkeys and more.

Cambridge NeuroTech Silicon Neural Probes for electrophysiology and optogenetics

Enjoy exceptional long-term in vivo stability and record from the same neurons for weeks to months, with minimally-invasive dimensions and seamless integration with our small-footprint chronic nano-Drives for combined electrophysiology + optogenetics.

We don't just provide great probes, we also make reusable, implantable ultra-small digital headstages which are plug-n-play with our probes, allowing you to create very compact and lightweight implants thereby facilitating naturalistic behaviour in the pushing your data-gathering to the limits in the smallest of animals!

Cambridge NeuroTech mini-amp-64 digital headstages for electrophysiology in mice and rats

Benefiting from superior signal to noise performance along with minimal sensitivity to photoelectric artefacts, our silicon neural probes enable highly quality single unit and local field potential data in a wide range of experimental preparations spanning in vitro brain organoids to freely-behaving primates.

PROBES EVERYWHERE ALL AT ONCE

Multi-probe and multi-target solutions

Using multiple probes in one target and / or across multiple targets brings exponential value-add to your data yield and quality but it's not always been easy to see how to achieve that goal... until now. Find out in 60s just how painless it can be to up-scale your experiments...

Cambridge NeuroTech silicon neural probes for multiple brain targets

BENEFITS AND ADVANTAGES

Why you should use our next-generation silicon neural probe technology...

Our silicon neural probes offer exceptional performance for both acute and chronic experiments, encompassing:

Superior chronic stability - unrivalled in vivo longevity - record the neurons you want across many days to weeks in freely behaving animals.

Optogenetics-safe - the only silicon neural probes on the market with minimized sensitivity to photo-electric artefacts making them the optimal choice for single unit recording + optogenetics.
Best-in-class signal to noise ratio - stabilized microelectrodes with typical 50 kOhm impedance; ~2x - 10x better than the competition!
Microdrive compatible - designed to fit our chronic nano-Drives with guaranteed alignment with drive-axis and convenient co-alignment with optrodes and fluidic cannulae.
Ultra-thin, robust and with sharpened-tips for dura-penetration - 15 micron thin silicon neural probes with minimal footprint yet still able to withstand considerable stress without breaking; super sharp tips capable of penetrating rodent dura.
Long-term reusable - acute probes and optrodes offering multiple re-uses across many months.

Proven technology - our silicon neural probes are used in everything from mice to monkeys - read a recent Nature paper using our probes.

Record ACROSS or ALONG multiple cell layers

We offer a diverse range of probes spanning from 65 - 3150 microns, with a range of probe geometries (check out our catalog for more details) and in each case, electrodes are arranged in poly-electrode grids to ensure high-resolution single unit recording and superior spike-sorting power.

Our innovative H-Series neural probes use our most advanced manufacturing technology to keep overall probe dimensions to a minimum; at <80 microns shank-width for 64 channels, these advanced silicon neural probes are minimally-invasive without sacrificing recording resolution or device-size and thus open up new horizons for high-resolution single unit recording and current-source-density analysis across and along cell layers.

Our F-, P- and E-series silicon neural probes offer you a variety of electrode layouts tailored to optimize electrode placement along cell layers such as the hippocampal principal cell layer, the cerebellar Purkinje cell layer and so on, or within and between cortical columns. Our L-series neural probes provide even larger tissue-span with wider inter-electrode spacing spanning 3.1 mm.

PROBE OPTIONS

Choose from bespoke 3-D probe stacking to create your dream-probe, along with breakout-wires for LFP, EEG / EMG recording and enjoy dura-penetrating probes with our sharpened probe tips; moreover, you'll also notice much less tissue drag as you descend to target too.

ECoG ARRAYS

High-resolution recording from the brain surface

At only 4 microns thick, our ECoG arrays readily conform to the brain surface and are straightforward to position and implant - that's 5x thinner than the nearest competitor (thickness = stiffness!). Small, low-impedance electrodes (12 or 80 micron diam. with ; impedance < 100 KOhm) ensure excellent signal-to-noise and spatial resolution whilst thru-holes, incorporated where possible, minimise the occurence of CSF-shunting between the brain and the ECoG array. Our ECoG arrays can also be combined with our penetrating silicon neural probes for true 3-D recording from within and across your region of interest.

Cambridge-Neurotech-ECoG-Arrays.jpg#asset:1448

LARGE ANIMAL PROBES

Deep reach high-density recording for non-human primates

You can now enjoy all of the benefits of our silicon neural probe technology in large animals / deep brain structures with our new M-series probes. Designed with non-human primates in mind, our M-series probes reach up to 15 mm deep and offer the choice of high-density single unit recording with 64 sites covering 632 microns (M1 style) or 1965 microns for trans-laminar single unit recording and high-resolution current source density analysis across multiple cell layers (M2 style). Slightly thicker than our regular probes (35 microns vs. 15 microns) our M-series probes remain the most minimally-invasive large animal probes around and with super-sharpened tips, you're assured of minimal compression and smooth movement into and through the brain. Our M-series probes are available in acute form for head-fixed animals and in fully-implantable form for chronic applications.

advanced-neural-probes-3.png#asset:638

NEURAL PROBE CONNECTOR OPTIONS

Plug-n-play electrophysiology

All of our probes are available in acute and chronic forms and offer superior signal-to-noise performance and outstanding chronic single unit stability, along with seamless integration with fiber-optics and near-zero photoelectric artefacts for optogenetics + electrophysiology too!

Silicon Neural Probe Connector Options

We are plug & play with all of the mainstream headstage pre-amplifier and data-acquisition solutions on the market.

Our acute silicon neural probes are mounted on a convenient printed circuit board allowing for straightforward mounting on a micro-manipulator and with appropriate cleaning your acute silicon neural probe can be reused many times.

Our chronic silicon neural probes are built around a highly flexible cable allowing in-brain adjustment of the probe with our innovative chronic nano-Drives. We offer a range of connector solutions using Omnetics, Molex and TDT ZIF-Clip connectors to enable highly-scalable, multi-probe implants in even the smallest of freely-behaving animals.

preamp-logos.jpg#asset:308

Silicon Neural Probes

World-leading silicon neural probes engineered for high-yield single unit electrophysiology with optogenetics

Our neuroscientist-designed range of silicon neural probes are optimized for large-scale single unit recording combined with optogenetics in freely-behaving, head-fixed and anaesthetised animals ranging from mice to monkeys and more.

PROBES EVERYWHERE ALL AT ONCE

Multi-probe and multi-target solutions

BENEFITS AND ADVANTAGES

Why you should use our next-generation silicon neural probe technology...

RELATED LINKS

Download our Catalog

Learn from the Experts