High-resolution microdrives for chronic silicon neural probes

and optogenetic fibre optic cannula implants

Designed to mate with our innovative silicon neural probes to allow precision in-brain movement in freely behaving animals, the nano-Drive offers you convenient co-alignment of fibre optics and fluidic cannulas in a small-footprint, lightweight device... even a mouse can carry multiple nano-Drives!

nano-Drive - the world’s smallest chronic multi-functional microdrive

  • Smallest, most accurate drives ever made - small 2 x 4 mm footprint, 0.5 gram weight, 205 μm/ turn with 5 mm travel.
  • Precision engineering - robust design with 2 μm tolerance ensures accuracy, enables sterilization and re-use.
  • Silicon neural probe compatible - purpose-designed to guarantee easy alignment of our probes with drive axis.
  • Optogenetics compatible - easily co-align our silicon neural probes with a fiber optic cannula across 5 different positions with respect to probe shanks.
  • Scalable to multi-loci implants -the small footprint of the nano-Drives facilitates targeting of multiple brain areas within the same animal, opening up network- and system-level experiments with combined recording and optogenetics.
  • Compact, low-profile implants - easily co-mount multiple drives per animal for large-scale, multi-loci network targeting and keep head-pieces minimally-sized to facilitate natural behavior.

Simple and convenient co-alignment of silicon neural probes and fiber optics

Our chronic nano-Drives are designed to precisely co-align fiber cannulas alongside our silicon neural probes with spatially defined separation (300 or 650 microns between the fiber and probe) so as to minimize local tissue damage arising from the fiber, whilst maintaining proximity to the neurons being recorded to spill sufficient light power to drive the expressed target opsin. Our solution to the problem of uniting electrodes with fibers optics allows both devices to be moved through the brain, together, in a freely-behaving animal.

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Small footprint, lightweight and scalable to multi-target implants

The uniquely small footprint of the nano-Drives facilitates implants targeting multiple brain regions, such as in the example shown above where orbitofrontal cortex in the right hemisphere and medial prefrontal cortex in the left hemisphere were implanted each with a 32 channel silicon neural probe. Note the small overall size of the implant; a benefit for your animals and their behavior. Click here to see real-time data from this animal.

Optrode assembly in action

A four-shank 64 channel probe with co-aligned fiber cannula smoothly penetrating the cortex [Courtesy of Maxym Myroshnychenko, Lab of Christopher Lapish, Indiana University - Purdue University Indianapolis, USA.]

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