Silicon Neural Probes

World-leading silicon neural probes enabling high-yield single unit electrophysiology combined with optogenetics

Frustrated by poor chronic performance of your silicon neural probes? Broken too many expensive, fragile silicon neural probes? Data contaminated by optogenetic photo-electric artefacts?

Our silicon neural probes are the only probes around that are purpose-engineered for combined electrophysiology and optogenetics, with minimal photoelectric artifacts and enhanced signal to noise ratio. Our innovative probe architecture enables guaranteed alignment between our silicon neural probes and our chronic nano-Drives with co-alignment with fiber optic cannulas too.

Next-generation silicon neural probe technology

Our silicon neural probes offer exceptional performance for both acute and chronic experiments, encompassing:

  • Superior chronic stability - unrivalled in vivo longevity - record the neurons you want across many days to weeks in freely behaving animals.
  • Optogenetics-safe - the only silicon neural probes on the market with minimized sensitivity to photo-electric artefacts making them the optimal choice for single unit recording + optogenetics.
  • Best-in-class signal to noise ratio - stabilized microelectrodes with typical 50 kOhm impedance; ~2x - 10x better than the competition!
  • Microdrive compatible - designed to fit our chronic nano-Drives with guaranteed alignment with drive-axis and convenient co-alignment with optrodes and fluidic cannulae.
  • Ultra-thin yet robust -15 micron thin silicon neural probes with narrow shank-width for minimal tissue damage yet still able to withstand considerable stress without breaking.
  • Long-term reusable - acute probes offering multiple re-uses across many months.
  • Proven technology - our silicon neural probes are used in everything from mice to monkeys - read a recent Nature paper using our probes.

RELATED LINKS

  • See a full summary of in-vivo data generated with our probes

Data speaks for itself!

Watch this short video of live data from a 32 channel probe in a freely behaving rat, using our wireless telemetry

Our probes make it in to Nature...

Read a recent Nature paper which uses our silicon neural probes in freely-behaving mice - see Figures 4, 5 & 6

Read More

Our advanced silicon neural probe microelectrodes

Our neuroscientist-designed range of silicon neural probe microelectrodes are optimized for single unit recording in anaesthetised, head-fixed and freely-behaving animals. All of our silicon neural probes record single units along with local field potential (LFP) signals too.

Record ACROSS multiple cell layers

Our innovative H-Series neural probes use our most advanced manufacturing technology to produce probes capable of spanning 1.3 mm without sacrificing single unit resolution or compromising tissue damage. At <80 micron wide for 64 channels, these innovative probes maintain a minimally-invasive footprint and open new horizons for trans-laminar single unit recording and high-resolution current source density analysis across multiple cell layers. You can now have the best of both worlds for multi-laminar coverage with minimal tissue damage:

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Our unique H1 / H1b probe style caters to those wanting to record the smallest units in the brain (i.e. granule cells) by utilizing the world's smallest ultra-high-density electrode array - meaning you can now record everything from the tiniest cells all the way up to a complete cortical span using our innovative H-series neural probes!

Record ALONG cell layers

Our F-, P- and E-series silicon neural probes offer you a variety of electrode layouts tailored to optimize electrode placement along cell layers such as the hippocampal principal cell layer, the cerebellar Purkinje cell layer and so on, or within and between cortical columns. The electrodes are arranged in poly-trode grids to ensure high-resolution single unit recording and superior spike-sorting power.

Cambridge Neurotech Silicon Neural Probes - record along cell layers

All of our probes are available in acute and chronic forms and offer superior signal-to-noise performance and outstanding chronic single unit stability, along with seamless integration with fiber-optics and near-zero photoelectric artefacts for optogenetics + electrophysiology too!

RELATED LINKS

High-resolution laminar recording in the hippocampus

See data from an H3 probe spanning rat CA1 to dentate gyrus with 20 micron resolution.

Ultra-thin robust probes - strength through flexibility

At only 15 microns thin, our silicon neural probes minimize tissue damage and enhance chronic performance - they're also really robust (i.e. grad-student proof!).

Acute Optrodes - ready-made, reusable and minimally-invasive

Take a closer look at our acute optrodes for single unit electrophysiology + optogenetics

Large animal probes - deep reach high-density recording for non-human primates

You can now enjoy all of the benefits of our silicon neural probe technology in large animals / deep brain structures with our new M-series probes. Designed with non-human primates in mind, our M-series probes reach up to 15 mm deep and offer the choice of high-density single unit recording with 64 sites covering 632 microns (M1 style) or 1965 microns for trans-laminar single unit recording and high-resolution current source density analysis across multiple cell layers (M2 style). Slightly thicker than our regular probes (35 microns vs. 15 microns) our M-series probes remain the most minimally-invasive large animal probes around and with super-sharpened tips, you're assured of minimal compression and smooth movement into and through the brain. Our M-series probes are available in acute form for head-fixed animals and in fully-implantable form for chronic applications.

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Plug & play pre-amplifier headstage connector options

We offer a variety of options for using our silicon neural probes in acute or chronic experiments and we are plug & play with all of the mainstream headstage pre-amplifier and data-acquisition solutions on the market.

Our acute silicon neural probes are mounted on a convenient printed circuit board allowing for straightforward mounting on a micro-manipulator and with appropriate cleaning your acute silicon neural probe can be reused many times.

Our chronic silicon neural probes are built around a highly flexible cable allowing in-brain adjustment of the probe with our innovative chronic nano-Drives. We offer a range of connector solutions using Omnetics connectors and Molex connectors to enable highly-scalable, multi-probe implants in even the smallest of freely-behaving animals.

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Our silicon neural probes are plug-n-play with all mainstream headstage pre-amplifiers:

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